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Tumor necrosis factor: a cytokine involved in toxic effects of endotoxin

Männel, Daniela N. ; Northoff, H. ; Bauss, F. ; Falk, Werner


Endotoxin-induced tumor necrosis has been shown to be mediated by a factor termed tumor necrosis factor (TNF). The biochemical nature, source, and mode of induction of TNF have been clarified. TNF is a mediator of activated macrophages that is released into the supernatant by these cells after their stimulation with endotoxin. A number of biologic functions of TNF other than its tumoricidal ...


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