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Normal lymphocyte responsiveness to lectins but impaired sensitivity to in vitro glucocorticoids in major depression.

URN to cite this document:
urn:nbn:de:bvb:355-epub-163250
DOI to cite this document:
10.5283/epub.16325
Wodarz, Norbert ; Rupprecht, R. ; Kornhuber, J. ; Schmitz, B. ; Wild, K. ; Braner, H. U. ; Riederer, P.
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Date of publication of this fulltext: 26 Aug 2010 07:09


Abstract

The mitogen-induced lymphocyte proliferative response and its sensitivity to in vitro (10(-10)-10(-6) M) dexamethasone (DEX) administration were investigated in 12 severely depressed patients and 13 healthy controls. Patients with major depressive disorder exhibited no impairment of lectin-induced blastogenesis, but a significantly weaker suppressive effect of in vitro DEX on 1.0 microgram/ml ...

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