3H-spiroperidol binding to human peripheral mononuclear cells: methodological aspects.

URN to cite this document:: urn:nbn:de:bvb:355-epub-163269
DOI to cite this document:: 10.5283/epub.16326

Wodarz, Norbert ; Fritze, J. ; Kornhuber, J. ; Riederer, P.

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Date of publication of this fulltext: 27 Aug 2010 12:23

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Abstract

3H-spiroperidol binding to lymphocytes has been proposed as a vulnerability marker for schizophrenia. However, the biological significance and even existence of this "binding site" are still in controversy. Therefore, the present study reevaluated methodological details using a filtration binding assay. The results indicated that some well-known, but obviously uncontrolled pitfalls might ...