Cell-mediated immunity and its glucocorticoid-sensitivity after clinical recovery from severe major depressive disorder.

URN to cite this document:: urn:nbn:de:bvb:355-epub-163280
DOI to cite this document:: 10.5283/epub.16328

Wodarz, Norbert ; Rupprecht, R. ; Kornhuber, J. ; Schmitz, B. ; Wild, K. ; Riederer, P.

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Date of publication of this fulltext: 27 Aug 2010 12:22

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Abstract

This follow-up study investigated lymphocyte blastogenesis induced by concanavalin A, phytohemagglutinin A, and pokeweed mitogen and their sensitivity to in vitro dexamethasone administration in 12 patients clinically recovered from severe major depression. Although cortisol-levels at 4.00 p.m. decreased significantly after clinical remission, mitogen-driven lymphocyte proliferative responses ...