Glucocorticoid receptors on mononuclear leukocytes in Alzheimer's disease

URN to cite this document:: urn:nbn:de:bvb:355-epub-163333
DOI to cite this document:: 10.5283/epub.16333

Rupprecht, R. ; Frölich, L. ; Mergenthaler, T. ; Kornhuber, J. ; Wodarz, Norbert ; Riederer, P. ; Maurer, K.

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Date of publication of this fulltext: 27 Aug 2010 12:18

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Abstract

Several lines of evidence suggest disturbances of the hypothalamic-pituitary-adrenal (HPA) system in Alzheimer's disease (AD). In an exploration of the potential role of the glucocorticoid receptor (GR) in AD, GR density and affinity were assessed on mononuclear leukocytes of 12 AD patients and 12 healthy controls. GR binding characteristics did not differ between patients and controls or between ...