Disturbed glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressives pretreated with metyrapone

URN to cite this document:: urn:nbn:de:bvb:355-epub-163366
DOI to cite this document:: 10.5283/epub.16336

Rupprecht, R. ; Kornhuber, J. ; Wodarz, Norbert ; Lugauer, J. ; Göbel, C. ; Haack, D. ; Beck, G. ; Müller, O. A. ; Riederer, P. ; Beckmann, H.

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Date of publication of this fulltext: 27 Aug 2010 12:16

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Abstract

We studied glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressed patients and controls, attempting to control for the confounding effect of endogenous glucocorticoids. After depletion of endogenous cortisol, depressed patients showed an attenuated suppressibility of corticotropin by dexamethasone in the face of unchanged dexamethasone plasma levels. ...