Rupprecht, R., Kornhuber, J., Wodarz, Norbert, Lugauer, J., Göbel, C., Haack, D., Beck, G., Müller, O. A., Riederer, P. and Beckmann, H.
(1991)
Disturbed glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressives pretreated with metyrapone.
Biological psychiatry 29 (11), pp. 1099-1109.
Date of publication of this fulltext: 27 Aug 2010 12:16at PubMed
Abstract
We studied glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressed patients and controls, attempting to control for the confounding effect of endogenous glucocorticoids. After depletion of endogenous cortisol, depressed patients showed an attenuated suppressibility of corticotropin by dexamethasone in the face of unchanged dexamethasone plasma levels. ...
Abstract
We studied glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressed patients and controls, attempting to control for the confounding effect of endogenous glucocorticoids. After depletion of endogenous cortisol, depressed patients showed an attenuated suppressibility of corticotropin by dexamethasone in the face of unchanged dexamethasone plasma levels. Beta-endorphin levels were strongly correlated with adrenocorticotropic hormone (ACTH) concentrations. Although metyrapone administration resulted in a marked rise of glucocorticoid receptor sites per cell in controls, this effect was not present in depressives. These data support the hypothesis of a decreased glucocorticoid receptor plasticity and a partial steroid resistance in depression.
Export bibliographical data
| Item type: | Article |
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| Date: | 1991 |
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| Institutions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
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| Identification Number: | | Value | Type |
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| 1651773 | PubMed ID |
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| Classification: | | Notation | Type |
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| Adolescent | MESH | | Adrenocorticotropic Hormone/blood | MESH | | Adult | MESH | | Aged | MESH | | Bipolar Disorder/psychology | MESH | | Depressive Disorder/psychology | MESH | | Dexamethasone/pharmacokinetics | MESH | | Female | MESH | | Homeostasis/physiology | MESH | | Humans | MESH | | Hydrocortisone/blood | MESH | | Hypothalamo-Hypophyseal System/physiopathology | MESH | | Male | MESH | | Metyrapone/diagnostic use | MESH | | Middle Aged | MESH | | Pituitary-Adrenal System/physiopathology | MESH | | Premedication | MESH | | Psychiatric Status Rating Scales | MESH | | Receptors, Glucocorticoid/physiology | MESH | | beta-Endorphin/blood | MESH |
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| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine |
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| Status: | Published |
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| Refereed: | Unknown |
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| Created at the University of Regensburg: | Unknown |
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| Item ID: | 16336 |
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