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In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression

Rupprecht, R., Wodarz, Norbert, Kornhuber, J., Wild, K., Schmitz, B., Braner, H.-U., Müller, O. A., Riederer, P. and Beckmann, H. (1991) In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression. European archives of psychiatry and clinical neuroscience 241 (1), pp. 35-40.

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Abstract

Twelve severely depressed patients and 13 healthy controls were studied under baseline, metyrapone and metyrapone plus dexamethasone pretreated conditions. Lymphocyte proliferation data were obtained by concanavalin A, phytohaemagglutinin and pokeweed mitogen (PWM) stimulation. There was a decrease in PWM-induced B-cell proliferation and an increase in inhibition of spontaneous leucocyte ...

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Item type:Article
Date:1991
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Identification Number:
ValueType
1653618PubMed ID
Classification:
NotationType
AdolescentMESH
Adrenocorticotropic Hormone/bloodMESH
AdultMESH
AgedMESH
Bipolar Disorder/immunologyMESH
Depressive Disorder/immunologyMESH
Dexamethasone/pharmacologyMESH
FemaleMESH
HumansMESH
Hydrocortisone/bloodMESH
Lymphocyte Activation/immunologyMESH
MaleMESH
Metyrapone/pharmacologyMESH
Middle AgedMESH
Receptors, Glucocorticoid/physiologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Item ID:16337
Owner only: item control page

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