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In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression

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Rupprecht, R. ; Wodarz, Norbert ; Kornhuber, J. ; Wild, K. ; Schmitz, B. ; Braner, H.-U. ; Müller, O. A. ; Riederer, P. ; Beckmann, H.
Date of publication of this fulltext: 27 Aug 2010 12:15


Twelve severely depressed patients and 13 healthy controls were studied under baseline, metyrapone and metyrapone plus dexamethasone pretreated conditions. Lymphocyte proliferation data were obtained by concanavalin A, phytohaemagglutinin and pokeweed mitogen (PWM) stimulation. There was a decrease in PWM-induced B-cell proliferation and an increase in inhibition of spontaneous leucocyte ...


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