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Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout

Pop, Nathalie (2010) Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout. PhD, Universität Regensburg.

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Date of publication of this fulltext: 03 Sep 2010 11:37

Abstract (English)

For the pharmacological characterization of GPCR ligands in addition to binding data, the determination of the quality of action, agonistic potency or antagonistic activity is a must. There are numerous methods to determine potency and efficacy of ligands at the GPCR of interest, each of which has its specific applications, advantages and disadvantages. Therefore, a maximum of information on a ...

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Translation of the abstract (German)

Für die pharmakologische Charakterisierung von GPCR Liganden ist zusätzlich zu Bindungsdaten die Bestimmung der Art ihrer Aktivität und ihrer agonistischen bzw. antagonistischen Potenz unerlässlich. Zahlreiche Methoden zur Bestimmung der Potenz und Effizienz solcher Liganden haben alle ihre spezifischen Anwendungsgebiete sowie Vorteile und Nachteile. Deswegen kann ein größtmöglicher ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:3 September 2010
Referee:Prof. Dr. Armin Buschauer
Date of exam:6 August 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Interdisciplinary Subject Network:Not selected
Keywords:Neuropeptid Y, NPY, Y Rezeptor, G-Protein gekoppelter Rezeptor, GPCR, Radioaktivität, Konstitutive Aktivität, Calcium Assay, Fluoreszenz, Aequorin, FRET, Epac; neuropeptide Y, G protein-coupled receptor, radioactivity, constitutive activity, fluorescence
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:16430
Owner only: item control page

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