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Characterisation of the metal-ion-GDP complex at the active sites of transforming and nontransforming p21 proteins by observation of the ¹⁷O-Mn superhyperfine coupling and by kinetic methods

Feuerstein, J. ; Kalbitzer, Hans Robert ; John, J. ; Goody, R. S. ; Wittinghofer, A.


Kinetic studies on the interaction of three Ha-ras-encoded p21 proteins with GDP and MgGDP have yielded values for the association (10(6)-10(7) M-1 s-1) and dissociation (10(-3)-10(-5) s-1) rate constants at 0 degrees C. Dramatic differences in the rate constants were not observed for the three proteins. Under non-physiological conditions (absence of Mg2+), the rate constant for GDP release was ...


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