Tumor-induced tumor necrosis factor production in macrophages

URN to cite this document:: urn:nbn:de:bvb:355-epub-164719
DOI to cite this document:: 10.5283/epub.16471

Männel, D. N. ; Jänicke, R. ; Westenfelder, U. ; Echtenacher, B. ; Kist, A. ; Falk, Werner

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Date of publication of this fulltext: 08 Sep 2010 05:21

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Abstract

Tumor-associated tumor necrosis factor (TNF) production in patients as well as a TNF-inducing membrane constituent of tumor cells have been reported. In a murine fibrosarcoma model we analyzed TNF production during growth of a tumor transplant. In situ hybridization showed that a gradually increasing number of cells within the tumor tissue became positive for TNFmRNA. Also, in spleen cells of ...