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Endogenous interferon specifically regulates Newcastle disease virus-induced cytokine gene expression in mouse macrophages

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Zawatzky, R. ; Wurmbaeck, H. ; Falk, Werner ; Homfeld, A.
Date of publication of this fulltext: 08 Sep 2010 05:18


In macrophages from inbred mice, the magnitude of the interferon (IFN) response to Newcastle disease virus (NDV) infection is under genetic control of the If-1 locus, which carries the allele for either high (h) or low (l) IFN production. Here, we report that the activity of genes within the If-1 locus is influenced by macrophage-derived endogenous IFN. In addition to various other biological ...


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