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Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry

URN to cite this document:
urn:nbn:de:bvb:355-epub-165508
DOI to cite this document:
10.5283/epub.16550
Wiesner, Philipp
Date of publication of this fulltext: 11 Oct 2010 09:42


Abstract (English)

Glycerophospholipid and sphingolipid species and their bioactive metabolites are important regulators of lipoprotein and cell function. Aim of the study was to develop a method for lipid species profiling of separated lipoprotein classes. Methods: Human serum lipoproteins VLDL, LDL and HDL of 21 healthy fasting blood donors were separated by fast performance liquid chromatography (FPLC) from 50 ...

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Translation of the abstract (German)

Cholesterin, Glycerophospho- und Sphingolipide und deren aktive Metaboliten sind wichtige Komponenten und Regulatoren des Lipoprotein- und Zellstoffwechsels. Phosphatidylcholin und Sphingomyelin dienen als Vorläufer der Verbindungen Lysophospatidylcholine bzw. Ceramide und regulieren darüber hinaus zentrale Schritte des Lipoproteinstoffwechsels. Neben der direkten Wirkung dieser Lipide auf den ...

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