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Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein

Geyer, M. ; Munte, C. E. ; Schorr, J. ; Kellner, R. ; Kalbitzer, Hans Robert


Negative factor (Nef) is a regulatory myristoylated protein of human immunodeficiency virus (HIV) that has a two-domain structure consisting of an anchor domain and a core domain separated by a specific cleavage site of the HIV proteases. For structural analysis, the HIV-1 Nef anchor domain (residues 2-57) was synthesized with a myristoylated and non-myristoylated N terminus. The structures of ...


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