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Crystal structure of the catalytic domains of membranous adenylyl cyclase with MANT-ITP and electrophysiological analysis of MANT nucleotides in cardiomyocytes

URN to cite this document:
urn:nbn:de:bvb:355-epub-166177
Hübner, Melanie
Date of publication of this fulltext: 14 Oct 2010 13:08


Abstract (English)

Adenylyl cyclases (ACs) play a crucial role in G protein-coupled receptor signaling, because they generate cyclic adenosine 3’,5’-monophosphate (cAMP). AC inhibitors could be applied when pathophysiological high cAMP concentrations are predominant, such as in heart failure or neurodegenerative disorders. 2’,3’-O-(N-Methylanthraniloyl)-nucleoside 5’-triphosphates (MANT-NTPs) are a new class of ...

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Translation of the abstract (German)

Adenylylzyklasen (ACs) spielen in der G-Protein-gekoppelten Rezeptor-Signalkaskade eine entscheidende Rolle, weil sie einen wichtigen intrazellulären Botenstoff, zyklisches Adenosinmonophosphat (cAMP), synthetisieren. AC-Inhibitoren könnten pharmakotherapeutisch bei pathophysiologisch erhöhten cAMP-Konzentrationen eingesetzt werden, die bei Herzinsuffizienz, aber auch bei neurodegenerativen ...

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