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Crystal structure of the catalytic domains of membranous adenylyl cyclase with MANT-ITP and electrophysiological analysis of MANT nucleotides in cardiomyocytes

Hübner, Melanie (2010) Crystal structure of the catalytic domains of membranous adenylyl cyclase with MANT-ITP and electrophysiological analysis of MANT nucleotides in cardiomyocytes. PhD, Universität Regensburg.

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Date of publication of this fulltext: 14 Oct 2010 13:08

Abstract (English)

Adenylyl cyclases (ACs) play a crucial role in G protein-coupled receptor signaling, because they generate cyclic adenosine 3’,5’-monophosphate (cAMP). AC inhibitors could be applied when pathophysiological high cAMP concentrations are predominant, such as in heart failure or neurodegenerative disorders. 2’,3’-O-(N-Methylanthraniloyl)-nucleoside 5’-triphosphates (MANT-NTPs) are a new class of ...

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Translation of the abstract (German)

Adenylylzyklasen (ACs) spielen in der G-Protein-gekoppelten Rezeptor-Signalkaskade eine entscheidende Rolle, weil sie einen wichtigen intrazellulären Botenstoff, zyklisches Adenosinmonophosphat (cAMP), synthetisieren. AC-Inhibitoren könnten pharmakotherapeutisch bei pathophysiologisch erhöhten cAMP-Konzentrationen eingesetzt werden, die bei Herzinsuffizienz, aber auch bei neurodegenerativen ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:11 October 2010
Referee:Prof. Dr. Roland Seifert and Prof. Dr. Stefan Dove
Date of exam:27 August 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Interdisciplinary Subject Network:Not selected
Keywords:Adenylatzyklase-Inhibitoren, MANT-Nukleotide, Röntgenkristallstruktur mit MANT-ITP, Kardiomyozyten, L-typ Calciumkanal, Elektrophysiologie; Adenylyl cyclase inhibitors, MANT nucleotides, crystal structure with MANT-ITP, cardiomyocytes, basal L-type calcium current, whole cell patch clamp technique
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:16617
Owner only: item control page

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