Rudolph, C., Sigruener, A., Hartmann, A., Orso, E., Bals-Pratsch, M., Gronwald, W., Seifert, B., Kalbitzer, Hans Robert, Verdorfer, I., Luetjens, C. M., Ortmann, O., Bornstein, S. R. and Schmitz, G.
(2007)
ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 39 (5), pp. 322-335.
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Abstract
The screening for additional human YjeF_N domain containing proteins beside the apolipoprotein A-I interacting protein (AI-BP), identified two other genes designated hYjeF_N2-15q23 (formerly human homologue of yeast edc3) and hYjeF_N3-19p13.11 comprising the human YjeF_N family. AI-BP is ubiquitously expressed, with a predominance of these tissues where the homologues were found to be restricted ...
Abstract
The screening for additional human YjeF_N domain containing proteins beside the apolipoprotein A-I interacting protein (AI-BP), identified two other genes designated hYjeF_N2-15q23 (formerly human homologue of yeast edc3) and hYjeF_N3-19p13.11 comprising the human YjeF_N family. AI-BP is ubiquitously expressed, with a predominance of these tissues where the homologues were found to be restricted including brain, mammary gland, testes and ovaries. Immunohistochemistry of human testes and ovaries showed an expression of hYjeF_N3-19p13.11 only in Leydig cells and theca cells, respectively, indicating a role in steroid hormone metabolism. Interestingly, the protein was also strongly expressed in Leydig cell tumors and in thecofibromas. The identification of hYjeF_N2-15q23 in theca cells and granulosa cells in ovaries, in human spermatids of meiotic division part II and the apical membrane of Sertoli cells in testes suggest similar functions in oogenesis and sperm maturation which is strengthened by the identification of the spermatogenesis regulator HMGA1 as a conserved transcription factor. However, in contrast to AI-BP, both homologous proteins are unable to bind apoA-I. These results relate the human YjeF_N domain containing protein family to cholesterol processing and steroid hormone metabolism in spermiogenesis and oogenesis, and AI-BP may link this function to the HDL pathway.
Export bibliographical data
| Item type: | Article |
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| Date: | 2007 |
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| Institutions: | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer |
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| Identification Number: | | Value | Type |
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| 17533573 | PubMed ID | | 10.1055/s-2007-977699 | DOI |
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| Classification: | | Notation | Type |
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| Adult | MESH | | Aged | MESH | | Aged, 80 and over | MESH | | Amino Acid Sequence | MESH | | Blotting, Northern | MESH | | Blotting, Western | MESH | | Carrier Proteins/physiology | MESH | | Child, Preschool | MESH | | DNA Probes | MESH | | DNA, Complementary/genetics | MESH | | Female | MESH | | Fibroma/pathology | MESH | | Genome, Human | MESH | | Humans | MESH | | Immunohistochemistry | MESH | | Leydig Cell Tumor/pathology | MESH | | Lipoproteins, HDL/physiology | MESH | | Male | MESH | | Middle Aged | MESH | | Molecular Sequence Data | MESH | | Oogenesis/physiology | MESH | | Ovary/cytology | MESH | | Pregnancy Proteins/physiology | MESH | | Promoter Regions, Genetic/genetics | MESH | | RNA/genetics | MESH | | Reverse Transcriptase Polymerase Chain Reaction | MESH | | Spermatogenesis/physiology | MESH | | Testicular Neoplasms/pathology | MESH | | Testis/cytology | MESH |
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| Dewey Decimal Classification: | 500 Science > 570 Life sciences |
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| Status: | Published |
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| Refereed: | Unknown |
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| Created at the University of Regensburg: | Unknown |
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| Item ID: | 16657 |
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