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Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains

Brügger, Britta, Krautkrämer, Ellen, Tibroni, Nadine, Munte, Claudia E., Rauch, Susanne, Leibrecht, Iris, Glass, Bärbel, Breuer, Sebastian, Geyer, Matthias, Kräusslich, Hans-Georg, Kalbitzer, Hans Robert, Wieland, Felix T. and Fackler, Oliver T. (2007) Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains. Retrovirology 4, p. 70.

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Abstract

BACKGROUND: The Nef protein of Human Immunodeficiency Viruses optimizes viral spread in the infected host by manipulating cellular transport and signal transduction machineries. Nef also boosts the infectivity of HIV particles by an unknown mechanism. Recent studies suggested a correlation between the association of Nef with lipid raft microdomains and its positive effects on virion infectivity. ...

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Item type:Article
Date:2007
Additional Information (public):Online-Ressource
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
16777597PubMed ID
10.1186/1742-4690-4-70DOI
Classification:
NotationType
Antigens, CD4/metabolismMESH
Cells, CulturedMESH
Cholesterol/metabolismMESH
Gene Products, gag/metabolismMESH
HIV-1/pathogenicityMESH
HumansMESH
Membrane Microdomains/virologyMESH
Phosphatidylcholines/metabolismMESH
Sphingomyelins/metabolismMESH
T-Lymphocytes/virologyMESH
Virion/pathogenicityMESH
Virus Replication/physiologyMESH
nef Gene Products, Human Immunodeficiency Virus/metabolismMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Item ID:16658
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