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Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains

Brügger, Britta ; Krautkrämer, Ellen ; Tibroni, Nadine ; Munte, Claudia E. ; Rauch, Susanne ; Leibrecht, Iris ; Glass, Bärbel ; Breuer, Sebastian ; Geyer, Matthias ; Kräusslich, Hans-Georg ; Kalbitzer, Hans Robert ; Wieland, Felix T. ; Fackler, Oliver T.


BACKGROUND: The Nef protein of Human Immunodeficiency Viruses optimizes viral spread in the infected host by manipulating cellular transport and signal transduction machineries. Nef also boosts the infectivity of HIV particles by an unknown mechanism. Recent studies suggested a correlation between the association of Nef with lipid raft microdomains and its positive effects on virion infectivity. ...


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