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Simulations on the selectivity of 5-aminolaevulinic acid-induced fluorescence in vivo

Ackermann, G. ; Abels, C. ; Bäumler, W. ; Langer, S. ; Landthaler, M. ; Lang, Elmar W. ; Szeimies, R. M.


The knowledge of the exact time course of a photosensitizer in tumour and surrounding host tissue is fundamental for effective photodynamic therapy (PDT) and fluorescence-based diagnosis. In this study the time course of porphyrin fluorescence following topical application of 5-aminolaevulinic acid (ALA) using different formulations, concentrations and incubation times has been measured in ...


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