Signal pulses of several 100 volts and currents of several amperes have been obtained at lateral surface contacts on normal-state YBa2Cu3O7-δ films in response to pulsed laser irradiation. The signals are shown to be of thermoelectric origin. Thermoelectric fields transverse to the laser-induced temperature gradient are due to the anisotropy of the thermopower in YBa2Cu3O7-δ giving rise to non-zero off-diagonal elements Sij propto α of the Seebeck tensor for films prepared with a tilt angle α between the film c-axis and the film surface normal. Large-tilt-angle films (up to α = 20°) could be grown on specially cut substrates and may be useful as almost wavelength-independent room temperature radiation detectors.