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Synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacological effect

Vogel, Susanne ; Barbic, Matej ; Juergenliemk, Guido ; Heilmann, Jörg



Abstract

Besides 2',4'-dihydroxy-4,6'-dimethoxy-3'-prenylchalcone and 4-acetoxy-2',4'-dihydroxy-6'-methoxy-3'-prenylchalcone, both phase II metabolites of xanthohumol in rats. Also a principally new chalcone, 3'-coumaroyl-2',4,4'-trihydroxy-6'-methoxychalcone, structurally derived from helichrysetin by introducing a second coumaroyl substructure at C-3' was synthesized. Furthermore new chalcones were ...

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