Startseite UR

Synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacological effect

Vogel, Susanne, Barbic, Matej, Juergenliemk, Guido und Heilmann, Jörg (2010) Synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacological effect. European journal of medicinal chemistry 45 (6), S. 2206-2213.

Im Publikationsserver gibt es leider keinen Volltext zu diesem Eintrag.


Zusammenfassung

Besides 2',4'-dihydroxy-4,6'-dimethoxy-3'-prenylchalcone and 4-acetoxy-2',4'-dihydroxy-6'-methoxy-3'-prenylchalcone, both phase II metabolites of xanthohumol in rats. Also a principally new chalcone, 3'-coumaroyl-2',4,4'-trihydroxy-6'-methoxychalcone, structurally derived from helichrysetin by introducing a second coumaroyl substructure at C-3' was synthesized. Furthermore new chalcones were ...

plus


Bibliographische Daten exportieren



Dokumentenart:Artikel
Datum:2010
Zusätzliche Informationen (Öffentlich):CAN 153:62048 26-4 Biomolecules and Their Synthetic Analogs 6754-58-1P Role: PAC (Pharmacological activity), RCT (Reactant), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacol. effect); 62014-87-3P (Helichrysetin); 189299-05-6P; 688359-98-0P (Xanthohumol H); 688360-01-2P; 688360-02-3P; 852638-41-6P; 1034276-32-8P; 1207843-45-5P; 1228673-64-0P; 1228673-65-1P; 1228673-66-2P; 1228673-67-3P; 1228673-68-4P; 1228673-69-5P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacol. effect); 123-11-5; 373-61-5 (Boron trifluoride-acetic acid (1:2); 480-66-0; 5533-00-6; 6515-06-6; 6515-21-5; 25983-76-0; 404597-94-0; 955950-40-0; 1044743-44-3 Role: RCT (Reactant), RACT (Reactant or reagent) (synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacol. effect); 2161-86-6P; 3098-38-2P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacol. effect)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann)
Identifikationsnummer:
WertTyp
2010:493108Andere
Stichwörter / Keywords:CD antigens Role: BSU (Biological study, unclassified), BIOL (Biological study) (CD54, TNFalpha induced expression inhibitor synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacol. effect) Cell adhesion molecules Role: BSU (Biological study, unclassified), BIOL (Biological study) (ICAM-1 (intercellular adhesion mol. 1), TNFalpha induced expression inhibitor synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacol. effect) Tumor necrosis factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (ICAM-1 induced expression inhibitor synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacol. effect) Structure-activity relationship (antioxidant synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacol. effect) Structure-activity relationship (inflammation-inhibiting synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacol. effect) Antioxidants (pharmaceutical synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacol. effect) Anti-inflammatory agents Cytotoxicity Human (synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacol. effect) Chalcones Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the ph chalcone deriv synthesis condensation reaction antioxidant antiinflammatory agent chalcone deriv synthesis condensation reaction cytotoxicity chalcone deriv synthesis condensation reaction
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:18 Okt 2010 14:18
Zuletzt geändert:24 Mai 2018 12:16
Dokumenten-ID:17170
Nur für Besitzer und Autoren: Kontrollseite des Eintrags
  1. Universität

Universitätsbibliothek

Publikationsserver

Kontakt:

Publizieren: oa@ur.de

Dissertationen: dissertationen@ur.de

Forschungsdaten: daten@ur.de

Ansprechpartner