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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Planta medica | ||||
| Publisher: | Thieme | ||||
| Volume: | 61 | ||||
| Number of Issue or Book Chapter: | 5 | ||||
| Page Range: | pp. 435-8 | ||||
| Date: | 1995 | ||||
| Additional Information (public): | CAN 124:245 1-3 Pharmacology 117-39-5 (Quercetin); 482-35-9 (Quercetin 3-O-beta -D-glucopyranoside); 548-75-4 (4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(beta -D-glucopyranosyloxy)-3,5,6-trihydroxy-); 19833-27-3 (Patuletin 3-O-beta -D-glucopyranoside); 30964-13-7 (1,5-Dicaffeoylquinic acid) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), BIOL (Biological study) (radical scavenger activity of dihydroxyflavonols and dicaffeoylquinic acid studied by inhibition of chemiluminescence) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) | ||||
| Identification Number: |
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| Keywords: | Radicals Role: ADV (Adverse effect, including toxicity), BSU (Biological study, unclassified), BIOL (Biological study) (radical scavenger activity of dihydroxyflavonols and dicaffeoylquinic acid studied by inhibition of chemiluminescence) Glycosides Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), BIOL (Biological study) (flavanol, radical scavenger activity of dihydroxyflavonols and dicaffeoylquinic acid studied by inhi Flavonoids Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), BIOL (Biological study) (oxo hydroxy, radical scavenger activity of dihydroxyflavonols and dicaffeoylquinic acid studied by i flavonol structure activity scavenger radical | ||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | No | ||||
| Item ID: | 17173 |
Abstract
To gain more insights into structure-activity relationships, four 3',4'-dihydroxyflavonols differing in the substitution of the A and C rings and 1,5-dicaffeoylquinic acid were evaluated for their ability to inhibit chemiluminescence of human neutrophils stimulated with opsonized zymosan or FMLP as well as in an enzymic system with H2O2 and horseradish peroxidase. It could be shown that an addnl. ...
Abstract
To gain more insights into structure-activity relationships, four 3',4'-dihydroxyflavonols differing in the substitution of the A and C rings and 1,5-dicaffeoylquinic acid were evaluated for their ability to inhibit chemiluminescence of human neutrophils stimulated with opsonized zymosan or FMLP as well as in an enzymic system with H2O2 and horseradish peroxidase. It could be shown that an addnl. o-dihydroxy structure in the A-ring, or a 6-methoxy group, resp., has no significant influence, thus confirming the o-dihydroxy group of the B-ring as the most important structural feature for the radical scavenger activity. It can be supposed that the main effect of the tested flavonols is based on their inhibition of myeloperoxidase, besides inhibition of enzymes involved in activating the NADPH-oxidase, and a direct reaction with oxygen radicals. Inhibition of chemiluminescence by 1,5-dicaffeoylquinic acid was in the same order as those obsd. with the flavonols.
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