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Radical scavenger activity of different 3',4'-dihydroxyflavonols and 1,5-dicaffeoylquinic acid studied by inhibition of chemiluminescence

Heilmann, Jörg, Merfort, Irmgard and Weiss, Manfred (1995) Radical scavenger activity of different 3',4'-dihydroxyflavonols and 1,5-dicaffeoylquinic acid studied by inhibition of chemiluminescence. Planta medica 61 (5), pp. 435-8.

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Abstract

To gain more insights into structure-activity relationships, four 3',4'-dihydroxyflavonols differing in the substitution of the A and C rings and 1,5-dicaffeoylquinic acid were evaluated for their ability to inhibit chemiluminescence of human neutrophils stimulated with opsonized zymosan or FMLP as well as in an enzymic system with H2O2 and horseradish peroxidase. It could be shown that an addnl. ...

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Item type:Article
Date:1995
Additional Information (public):CAN 124:245 1-3 Pharmacology 117-39-5 (Quercetin); 482-35-9 (Quercetin 3-O-beta -D-glucopyranoside); 548-75-4 (4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(beta -D-glucopyranosyloxy)-3,5,6-trihydroxy-); 19833-27-3 (Patuletin 3-O-beta -D-glucopyranoside); 30964-13-7 (1,5-Dicaffeoylquinic acid) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), BIOL (Biological study) (radical scavenger activity of dihydroxyflavonols and dicaffeoylquinic acid studied by inhibition of chemiluminescence)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
1995:927318Other
Keywords:Radicals Role: ADV (Adverse effect, including toxicity), BSU (Biological study, unclassified), BIOL (Biological study) (radical scavenger activity of dihydroxyflavonols and dicaffeoylquinic acid studied by inhibition of chemiluminescence) Glycosides Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), BIOL (Biological study) (flavanol, radical scavenger activity of dihydroxyflavonols and dicaffeoylquinic acid studied by inhi Flavonoids Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), BIOL (Biological study) (oxo hydroxy, radical scavenger activity of dihydroxyflavonols and dicaffeoylquinic acid studied by i flavonol structure activity scavenger radical
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:17173
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