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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Planta medica | ||||
| Verlag: | Thieme | ||||
| Band: | 62 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 4 | ||||
| Seitenbereich: | S. 289-292 | ||||
| Datum: | 1996 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 125:292771 1-10 Pharmacology 102-32-9 (3,4-Dihydroxyphenylacetic acid); 501-97-3 (3-(4-Hydroxyphenyl)propionic acid); 621-37-4 (3-Hydroxyphenylacetic acid) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), MFM (Metabolic formation), BIOL (Biological study), FORM (Formation, nonpreparative) (radical scavenger activity of flavonoid metabolites detd. by inhibition of chemiluminescence in human PMNs); 117-39-5 (Quercetine) Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (radical scavenger activity of flavonoid metabolites detd. by inhibition of chemiluminescence in human PMNs); 7722-84-1 (Hydrogen peroxide); 9003-99-0 (Peroxidase) Role: RCT (Reactant), RACT (Reactant or reagent) (radical scavenger activity of flavonoid metabolites detd. by inhibition of chemiluminescence in human PMNs) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Luminescence Neutrophil (radical scavenger activity of flavonoid metabolites detd. by inhibition of chemiluminescence in human PMNs) Radicals Role: ANT (Analyte), BPR (Biological process), BSU (Biological study, unclassified), ANST (Analytical study), BIOL (Biological study), PROC (Process) (radical scavenger activity of flavonoid metabolites detd. by inhibition of chemiluminescence Procyanidins Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (radical scavenger activity of flavonoid metabolites detd. by inhibition of chemiluminescence in human PMNs) Flavonoids Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (oxo, radical scavenger activity of flavonoid metabolites detd. by inhibition of chemiluminescence in human PMNs) radical scavenger flavonoid metabolite | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Nein | ||||
| Dokumenten-ID: | 17174 |
Zusammenfassung
3,4-Dihydroxyphenylacetic acid (I), 3-hydroxyphenylacetic acid (II), and 3-(4-hydroxyphenyl)propionic acid (III), metabolites which arise from quercetin glycosides, resp., from flavones and probably from procyanidins by the human intestinal microflora, have been tested for their effects on oxygen radical prodn. by human PNMs stimulated with FMLP or opsonized zymosan. Oxygen radicals were detected ...
Zusammenfassung
3,4-Dihydroxyphenylacetic acid (I), 3-hydroxyphenylacetic acid (II), and 3-(4-hydroxyphenyl)propionic acid (III), metabolites which arise from quercetin glycosides, resp., from flavones and probably from procyanidins by the human intestinal microflora, have been tested for their effects on oxygen radical prodn. by human PNMs stimulated with FMLP or opsonized zymosan. Oxygen radicals were detected by luminol-augmented chemiluminescence measurements. Furthermore free radical scavenging activity of these metabolites was investigated in a cell-free system in which oxygen radicals were generated by horseradish peroxidase with H2O2 as substrate. I reduced considerably chemiluminescence in PMNs in an amt. which was much more pronounced than those of the two metabolites. Concns. of 1 micro mol/l showed an inhibition by 84% with FMLP as stimulant and by 15% with opsonized zymosan, indicating that different signal transduction pathways are influenced in PMNs. Using the same conditions the unmetabolized quercetin showed an inhibition of chemiluminescence by 74% (FMLP), resp. 20% (opsonized zymosan). In the cell-free system I suppressed much more effectively chemiluminescence than II. In contrast, III led to an increase of chemiluminescence generated in the cell-free system (FMLP and zymosan), i.e. by 30% and by 25%, at the highest concn. of 4 micro mol/l. In conclusion, flavonoid metabolites differ in their effects on free radical prodn. of PMNs and their radical scavenging potencies.
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