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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Journal of natural products | ||||
| Verlag: | American Chemical Society | ||||
| Band: | 63 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 3 | ||||
| Seitenbereich: | S. 339-343 | ||||
| Datum: | 2000 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 132:276414 10-1 Microbial, Algal, and Fungal Biochemistry 263842-17-7P (Comnostin B) Role: AGR (Agricultural use), BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (novel extracellular diterpenoids with biol. activity from the cyanobacterium Nostoc commune); 263842-16-6P (Comnostin A); 263842-18-8P (Comnostin C); 263842-19-9P (Comnostin D); 263842-20-2P (Comnostin E) Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (novel extracellular diterpenoids with biol. activity from the cyanobacterium Nostoc commune) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Animal cell line (Caco-2 cytotoxic and molluscicidal activities of comnostin B from Nostoc commune) Animal cell line (KB cytotoxic and molluscicidal activities of comnostin B from Nostoc commune) Antitumor agents (carcinoma cytotoxic and molluscicidal activities of comnostin B from Nostoc commune) New natural products (comnostins A-E (diterpenoids) Biomphalaria glabrata Molluscicides (cytotoxic and molluscicidal activities of comnostin B from Nostoc commune) Antibiotics Configuration (novel extracellular diterpenoids with biol. activity from the cyanobacterium Nostoc commune) Diterpenes Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence Crystal structure (of comnostin A) Molecular structure (of comnostins A-E (diterpenoids) cyanobacteria bioactive diterpenoid comnostin bioactive diterpenoid Nostoc antibiotic comnostin Nostoc molluscicide comnostin B Nostoc cytotoxicity comnostin B Nostoc crystal structure comnostin A | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Nein | ||||
| Dokumenten-ID: | 17186 |
Zusammenfassung
Five novel extracellular metabolites with an unprecedented diterpenoid skeleton and designated comnostins A-D (I-IV, resp.) and E have been isolated from the culture medium of the terrestrial cyanobacterium Nostoc commune by means of bioguided isolation. The structures were detd. by spectroscopic methods, mainly NMR and mass spectrometry. The relative stereochem. of I was confirmed by ...
Zusammenfassung
Five novel extracellular metabolites with an unprecedented diterpenoid skeleton and designated comnostins A-D (I-IV, resp.) and E have been isolated from the culture medium of the terrestrial cyanobacterium Nostoc commune by means of bioguided isolation. The structures were detd. by spectroscopic methods, mainly NMR and mass spectrometry. The relative stereochem. of I was confirmed by single-crystal X-ray structure anal. All comnostins showed antibacterial activities. Addnl., cytotoxic and molluscicidal activities were found for II.
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