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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Phytochemistry | ||||
| Verlag: | Elsevier | ||||
| Band: | 55 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 8 | ||||
| Seitenbereich: | S. 941-947 | ||||
| Datum: | 2000 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 134:219730 11-1 Plant Biochemistry 329371-34-8P; 329371-35-9P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors); 329371-36-0P; 329371-37-1P Role: BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors); 74434-59-6 (Sauvagine) Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors); 329371-38-2P; 329371-39-3P Role: PRP (Properties), SPN (Synthetic preparation), PREP (Preparation) (prepn. and properties of) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | New natural products (bisanthraquinone glycosides from Hypericum perforatum) St.-John's-wort (bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors) Glycosides Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) ( Molecular structure (of bisanthraquinone glycosides from Hypericum perforatum) Corticotropin releasing factor receptors Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (type I bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors) bisanthraquinone glycoside Hypericum corticotropin releasing hormone receptor binding inhibitor | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Nein | ||||
| Dokumenten-ID: | 17191 |
Zusammenfassung
Four new bisanthraquinone glycosides, S-(+)-skyrin-6-O-beta -glucopyranoside (e.g. I), R-(-)-skyrin-6-O-beta -glucopyranoside (e.g. II), S-(+)-skyrin-6-O-beta -xylopyranoside and S-(+)-skyrin-6-O-beta -alpha -arabinofuranoside, have been isolated from an ethanol-water (1:1, vol./vol.) dry ext. of the aerial parts of Hypericum perforatum L. The structures were elucidated by spectroscopic methods, ...
Zusammenfassung
Four new bisanthraquinone glycosides, S-(+)-skyrin-6-O-beta -glucopyranoside (e.g. I), R-(-)-skyrin-6-O-beta -glucopyranoside (e.g. II), S-(+)-skyrin-6-O-beta -xylopyranoside and S-(+)-skyrin-6-O-beta -alpha -arabinofuranoside, have been isolated from an ethanol-water (1:1, vol./vol.) dry ext. of the aerial parts of Hypericum perforatum L. The structures were elucidated by spectroscopic methods, mainly NMR and mass spectrometry. CD was used to det. their axial stereochem. revealing I and II to be atropisomers. I and II inhibited [125 I]sauvagine binding to corticotropin releasing hormone (CRH-1) receptors.
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