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Bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors

Wirz, A. ; Simmen, U. ; Heilmann, Jörg ; Calis, I. ; Meier, B. ; Sticher, Otto


Four new bisanthraquinone glycosides, S-(+)-skyrin-6-O-beta -glucopyranoside (e.g. I), R-(-)-skyrin-6-O-beta -glucopyranoside (e.g. II), S-(+)-skyrin-6-O-beta -xylopyranoside and S-(+)-skyrin-6-O-beta -alpha -arabinofuranoside, have been isolated from an ethanol-water (1:1, vol./vol.) dry ext. of the aerial parts of Hypericum perforatum L. The structures were elucidated by spectroscopic methods, ...


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