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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Journal of natural products | ||||
| Verlag: | American Chemical Society | ||||
| Band: | 64 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 7 | ||||
| Seitenbereich: | S. 961-964 | ||||
| Datum: | 2001 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 135:192855 11-1 Plant Biochemistry 573-44-4 (Liriodendrin); 14259-45-1 (Asperuloside); 18842-98-3 (Paederosidic acid); 18842-99-4 (Scandoside); 18843-01-1 (Deacetylasperuloside); 20547-45-9 (Paederoside); 25368-11-0 (Asperulosidic acid); 27741-01-1 (Geniposidic acid); 71144-68-8; 112747-98-5 (7S,8R,8'R-(-)-lariciresinol-4,4'-bis-O-beta -D-glucopyranoside) Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (flavonoid, iridoid, and lignan glycosides from Putoria calabrica and their radical scavenging activities); 356518-09-7P; 356518-10-0P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (flavonoid, iridoid, and lignan glycosides from Putoria calabrica and their radical scavenging activities) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | New natural products (calabricosides A and B (flavonoid glycosides) Putoria calabrica Radical scavengers (flavonoid, iridoid, and lignan glycosides from Putoria calabrica and their radical scavenging activities) Glycosides Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) ( flavonoid, iridoid, and lignan glycosides from Putoria calabrica and their radical scavenging activities) Lignans Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (glycosides flavonoid, iridoid, and lignan glycosides from Putoria calabrica and their radical scavenging activities) Aglycons Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (iridoid flavonoid, iridoid, and lignan glycosides from Putoria calabrica and their radical scavenging activities) Glycosides Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (lignan flavonoid, iridoid, and lignan glycosides from Putoria calabrica and their radical scavenging activities) Molecular structure (of calabricosides A and B (flavonoid glycosides) flavonoid glycoside Putoria radical scavenger iridoid Putoria radical scavenger lignan glycoside radical scavenger | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Nein | ||||
| Dokumenten-ID: | 17192 |
Zusammenfassung
From the aerial parts of Putoria calabrica, two new flavonol triglycosides were isolated and their structures were elucidated as quercetin-3-O-[alpha -L-rhamnopyranosyl-(1->2)-alpha -L-arabinopyranoside]-7-O-beta -D-glucopyranoside (I, calabricoside A) and quercetin-3-O-[4'''-O-caffeoyl-alpha -L-rhamnopyranosyl-(1->2)-alpha -L-arabinopyranoside]-7-O-beta -D-glucopyranoside (II, calabricoside B). ...
Zusammenfassung
From the aerial parts of Putoria calabrica, two new flavonol triglycosides were isolated and their structures were elucidated as quercetin-3-O-[alpha -L-rhamnopyranosyl-(1->2)-alpha -L-arabinopyranoside]-7-O-beta -D-glucopyranoside (I, calabricoside A) and quercetin-3-O-[4'''-O-caffeoyl-alpha -L-rhamnopyranosyl-(1->2)-alpha -L-arabinopyranoside]-7-O-beta -D-glucopyranoside (II, calabricoside B). Addnl., seven iridoid and three lignan glycosides were isolated and characterized. Radical scavenging activities of all compds. were detd. by quantifying their effects on luminol-enhanced chemiluminescence in formyl-methionyl-leucyl-phenylalanine (FMLP) stimulated human polymorphonuclear neutrophils (PMNs). Calabricoside A and B showed strong radical scavenging activity with IC50 values of 0.25 and 0.3 micro M, resp.
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