Alternative Links zum Volltext:
Zusammenfassung
A new cytotoxic 1,7-dioxa-dispiro[5.1.5.2]pentadeca-9,12-dien-11-one deriv., aculeatin D (I), and a new alkenone, 5-hydroxy-hexacos-1-en-3-one , have been isolated as minor compds. from the rhizomes of Amomum aculeatum. Their structures have been detd. mainly by NMR spectroscopy and mass spectrometry. Aculeatin D showed high cytotoxicity against the KB and the L-6 cell line with IC50 of 0.38 ...
Zusammenfassung
A new cytotoxic 1,7-dioxa-dispiro[5.1.5.2]pentadeca-9,12-dien-11-one deriv., aculeatin D (I), and a new alkenone, 5-hydroxy-hexacos-1-en-3-one , have been isolated as minor compds. from the rhizomes of Amomum aculeatum. Their structures have been detd. mainly by NMR spectroscopy and mass spectrometry. Aculeatin D showed high cytotoxicity against the KB and the L-6 cell line with IC50 of 0.38 micro g/mL and 1 micro g/mL, resp. Addnl., it revealed remarkable activity against two Plasmodium falciparum strains, as well as against Trypanosoma brucei rhodesiense and Trypanosoma cruzi. 5-Hydroxy-hexacos-1-en-3-one exhibited neither cytotoxic nor antiprotozoal activity, whereas antibacterial testing against Bacillus cereus, Escherichia coli and Staphylococcus epidermidis showed moderate to strong activity for both compds.
Altmetric