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Two novel cyclic peptides with antifungal activity from the cyanobacterium Tolypothrix byssoidea (EAWAG 195)

Jaki, B. ; Zerbe, O. ; Heilmann, Jörg ; Sticher, Otto



Zusammenfassung

Two novel cyclic tridecapeptides, tolybyssidins A and B, were isolated from the culture medium of mass cultured cyanobacterium Tolypothrix byssoidea (EAWAG 195) by means of bioguided isolation. The gross structures of these peptides were detd. by 1D and 2D NMR expts. and tandem mass spectrometry. Both peptides contain the nonnatural amino acid dehydrohomoalanine (Dhha) as well as proteinogenic ...

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