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Zusammenfassung
Using cytotoxicity against the KB cancer cell line (ATCC CCL17) as a lead, bioactivity-guided fractionation of the MeOH-sol. part of the DCM ext. of Warionia saharae leaves led to the isolation of six new cytotoxic guaianolide type sesquiterpene lactones (I-VI). Besides two guaianolides showing the common 6,7-trans fused lactone ring (III and IV), four compds. exhibiting the more rare 6,7-cis ...
Zusammenfassung
Using cytotoxicity against the KB cancer cell line (ATCC CCL17) as a lead, bioactivity-guided fractionation of the MeOH-sol. part of the DCM ext. of Warionia saharae leaves led to the isolation of six new cytotoxic guaianolide type sesquiterpene lactones (I-VI). Besides two guaianolides showing the common 6,7-trans fused lactone ring (III and IV), four compds. exhibiting the more rare 6,7-cis configuration (I,II and V,VI) were also isolated. Compds. I, II, V, and VI showed an unprecedented ether bridge between C-2 and C-4. The structures were deduced from extensive 1D and 2D NMR spectroscopy (1H, 13C, DQF-COSY, HSQC, HMBC, ROESY), as well as mass spectrometry (EI and HR-MALDI). Cytotoxicity testing against the KB cancer cell line revealed IC50 values of 1.0 (I), 4.5 (II), 1.7 (III), 2.0 (IV), 3.3 (V), and 5.5 (VI) micro g/mL.
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