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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Phytochemistry | ||||
| Verlag: | Elsevier | ||||
| Band: | 61 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 8 | ||||
| Seitenbereich: | S. 975-978 | ||||
| Datum: | 2002 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 138:251471 11-1 Plant Biochemistry 485-35-8 ((-)-Cytisine); 486-86-2 ((-)-N-Methylcytisine); 486-88-4 ((-)-Lupanine); 486-89-5 ((-)-Anagyrine); 486-90-8 ((-)-Thermopsine); 529-78-2 ((-)-Rhombifoline); 732-50-3 ((-)-Baptifoline); 6835-75-2 ((-)-Epibaptifoline); 33023-11-9 ((-)-Tinctorine); 121312-83-2 ((+)-5,6-Dehydrolupanine); 278617-91-7 ((-)-6alpha -Hydroxylupanine) Role: NPO (Natural product occurrence), BIOL (Biological study), OCCU (Occurrence) (quinolizidine alkaloids from curare adjuvant Clathrotropis glaucophylla); 502686-87-5 ((-)-Clathrotropine) Role: NPO (Natural product occurrence), PRP (Properties), BIOL (Biological study), OCCU (Occurrence) (quinolizidine alkaloids from curare adjuvant Clathrotropis glaucophylla) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | New natural products ((-)-clathrotropine (quinolizidine alkaloid) Toxins (curare quinolizidine alkaloids from curare adjuvant Clathrotropis glaucophylla) Molecular structure (of (-)-clathrotropine) Bark Clathrotropis glaucophylla (quinolizidine alkaloids from curare adjuvant Clathrotropis glaucophylla) Alkaloids Role: NPO (Natural product occurrence), PRP (Properties), BIOL (Biological study), OCCU (Occurrence) (quinolizidine quinolizidine alkaloids from curare adjuvant Clathrotropis glaucophylla) Clathrotropis bark quinolizidine alkaloid curare | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Nein | ||||
| Dokumenten-ID: | 17206 |
Zusammenfassung
The bark of Clathrotropis glaucophylla (Fabaceae) is used as admixt. of curare arrow poison by the Yanomami Amerindians in Venezuela. A new quinolizidine alkaloid (QA), (-)-13alpha -hydroxy-15alpha -(1-hydroxyethyl)-anagyrine [(-)-clathrotropine] (I), was isolated from the alkaloid ext. of C. glaucophylla bark, together with eleven known QAs: (-)-anagyrine, (-)-thermopsine, (-)-baptifoline, ...
Zusammenfassung
The bark of Clathrotropis glaucophylla (Fabaceae) is used as admixt. of curare arrow poison by the Yanomami Amerindians in Venezuela. A new quinolizidine alkaloid (QA), (-)-13alpha -hydroxy-15alpha -(1-hydroxyethyl)-anagyrine [(-)-clathrotropine] (I), was isolated from the alkaloid ext. of C. glaucophylla bark, together with eleven known QAs: (-)-anagyrine, (-)-thermopsine, (-)-baptifoline, (-)-epibaptifoline, (-)-rhombifoline, (-)-tinctorine, (-)-cytisine, (-)-N-methylcytisine, (-)-lupanine, (-)-6alpha -hydroxylupanine and (+)-5,6-dehydrolupanine. The isolation and structure elucidation were performed with the aid of chromatog. (TLC, HPLC and CC) and spectroscopic (UV and 1D/2D NMR) methods, and mass spectrometry. To our knowledge, this is the first time quinolizidine alkaloids have been isolated from an arrow poison ingredient. It is also the first report on Clathrotropis species being used for prepn. of arrow poison.
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