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Influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in Jurkat T cells and human peripheral blood cells: anti-inflammatory and cytotoxic effects

Gertsch, Jurg ; Sticher, Otto ; Schmidt, Thomas ; Heilmann, Jörg



Abstract

Sesquiterpene lactones (SLs) are known to have potent anti-inflammatory and cytotoxic properties. So far, the anti-inflammatory effects have mainly been attributed to their inhibition of DNA-binding of the transcription factor NF-kB (p65), which is a pivotal regulator of the cellular immune response. Since NF-kB is involved in the transcriptional control of several pro-inflammatory and regulatory ...

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