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Influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in Jurkat T cells and human peripheral blood cells: anti-inflammatory and cytotoxic effects

Gertsch, Jurg, Sticher, Otto, Schmidt, Thomas und Heilmann, Jörg (2003) Influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in Jurkat T cells and human peripheral blood cells: anti-inflammatory and cytotoxic effects. Biochemical Pharmacology 66 (11), S. 2141-2153.

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Zusammenfassung

Sesquiterpene lactones (SLs) are known to have potent anti-inflammatory and cytotoxic properties. So far, the anti-inflammatory effects have mainly been attributed to their inhibition of DNA-binding of the transcription factor NF-kB (p65), which is a pivotal regulator of the cellular immune response. Since NF-kB is involved in the transcriptional control of several pro-inflammatory and regulatory ...

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Dokumentenart:Artikel
Datum:2003
Zusätzliche Informationen (Öffentlich):CAN 140:174629 1-6 Pharmacology 302788-42-7 Role: BSU (Biological study, unclassified), BIOL (Biological study) (gene for; influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects); 6754-13-8 (Helenalin); 36505-53-0 (Dihydrohelenalin acetate); 78853-98-2 (Chamissonolide) Role: DMA (Drug mechanism of action), PAC (Pharmacological activity), BIOL (Biological study) (influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects); 501433-35-8 (INOS) Role: BSU (Biological study, unclassified), BIOL (Biological study) (mRNA; influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann)
Identifikationsnummer:
WertTyp
2003:885311Andere
Stichwörter / Keywords:Gene Role: BSU (Biological study, unclassified), BIOL (Biological study) (Bcl-2 influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Cyclins Role: BSU (Biological study, unclassified), BIOL (Biological study) (D1, gene for influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Transcription factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (IkB-alpha (NF-kB inhibitor alpha ), gene for influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Animal cell line (JURKAT influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Transcription factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (NF-kB (nuclear factor of k light chain gene enhancer in B-cells) influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Transcription factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (NFAT2 (nuclear factor of activated T-cell, 2), gene for influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Immunity (cell-mediated influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Gene Role: BSU (Biological study, unclassified), BIOL (Biological study) (house-keeping influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Anti-inflammatory agents Apoptosis Cytotoxic agents Human Mononuclear cell Transcription (influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Transcriptome mRNA Role: BSU (Biological study, unclassified), BIOL (Biological study) (influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic e Sesquiterpenes Role: DMA (Drug mechanism of action), PAC (Pharmacological activity), BIOL (Biological study) (lactones influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Cytokines Role: BSU (Biological study, unclassified), BIOL (Biological study) (mitogen-induced influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Proteins Role: BSU (Biological study, unclassified), BIOL (Biological study) (p65, gene for influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Actins Role: BSU (Biological study, unclassified), BIOL (Biological study) (beta -, gene for influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) helenanolide sesquiterpene lactone apoptosis antiinflammatory cytotoxic NFkappaB
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Nein
Eingebracht am:18 Okt 2010 12:27
Zuletzt geändert:24 Mai 2018 12:16
Dokumenten-ID:17212
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