Influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in Jurkat T cells and human peripheral blood cells: anti-inflammatory and cytotoxic effects
Article
Gertsch, Jurg, Sticher, Otto, Schmidt, Thomas and Heilmann, Jörg (2003) Influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in Jurkat T cells and human peripheral blood cells: anti-inflammatory and cytotoxic effects. Biochemical Pharmacology 66 (11), pp. 2141-2153.Alternative links to fulltext
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Details
| Item type | Article | ||||
| Journal or Publication Title | Biochemical Pharmacology | ||||
| Publisher | Elsevier | ||||
| Volume | 66 | ||||
| Number of Issue or Book Chapter | 11 | ||||
| Page Range | pp. 2141-2153 | ||||
| Date | 2003 | ||||
| Date of publication | 18 Oct 2010 12:27 | ||||
| Additional Information (public) | CAN 140:174629 1-6 Pharmacology 302788-42-7 Role: BSU (Biological study, unclassified), BIOL (Biological study) (gene for; influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects); 6754-13-8 (Helenalin); 36505-53-0 (Dihydrohelenalin acetate); 78853-98-2 (Chamissonolide) Role: DMA (Drug mechanism of action), PAC (Pharmacological activity), BIOL (Biological study) (influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects); 501433-35-8 (INOS) Role: BSU (Biological study, unclassified), BIOL (Biological study) (mRNA; influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) | ||||
| Institutions | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) | ||||
| Identification Number |
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| Keywords | Gene Role: BSU (Biological study, unclassified), BIOL (Biological study) (Bcl-2 influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Cyclins Role: BSU (Biological study, unclassified), BIOL (Biological study) (D1, gene for influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Transcription factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (IkB-alpha (NF-kB inhibitor alpha ), gene for influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Animal cell line (JURKAT influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Transcription factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (NF-kB (nuclear factor of k light chain gene enhancer in B-cells) influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Transcription factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (NFAT2 (nuclear factor of activated T-cell, 2), gene for influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Immunity (cell-mediated influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Gene Role: BSU (Biological study, unclassified), BIOL (Biological study) (house-keeping influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Anti-inflammatory agents Apoptosis Cytotoxic agents Human Mononuclear cell Transcription (influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Transcriptome mRNA Role: BSU (Biological study, unclassified), BIOL (Biological study) (influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic e Sesquiterpenes Role: DMA (Drug mechanism of action), PAC (Pharmacological activity), BIOL (Biological study) (lactones influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Cytokines Role: BSU (Biological study, unclassified), BIOL (Biological study) (mitogen-induced influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Proteins Role: BSU (Biological study, unclassified), BIOL (Biological study) (p65, gene for influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) Actins Role: BSU (Biological study, unclassified), BIOL (Biological study) (beta -, gene for influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in JURKAT and human mononuclear cells and mechanism of their anti-inflammatory and cytotoxic effects) helenanolide sesquiterpene lactone apoptosis antiinflammatory cytotoxic NFkappaB | ||||
| Dewey Decimal Classification | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||
| Status | Published | ||||
| Refereed | Yes, this version has been refereed | ||||
| Created at the University of Regensburg | No | ||||
| Item ID | 17212 |
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