Alternative links to fulltext:
| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Planta medica | ||||
| Publisher: | Thieme | ||||
| Volume: | 69 | ||||
| Number of Issue or Book Chapter: | 5 | ||||
| Page Range: | pp. 420-424 | ||||
| Date: | 2003 | ||||
| Additional Information (public): | CAN 139:377900 11-1 Plant Biochemistry 623943-73-7P (Piscatorin) Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum); 17951-19-8P (Justicidin B) Role: BSU (Biological study, unclassified), PUR (Purification or recovery), BIOL (Biological study), PREP (Preparation) (antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) | ||||
| Identification Number: |
| ||||
| Keywords: | Antibiotics Fungicides Phyllanthus piscatorum Protozoacides (antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum) Toxins Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (cytotoxins antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum) Molecular structure (of piscatorin (arylnaphthalide lignan) New natural products (piscatorin (arylnaphthalide lignan) Pesticides (piscicides antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum) Phyllanthus justicidin B piscatorin fungicide protozoacide cytotoxin piscicide | ||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | No | ||||
| Item ID: | 17213 |
Abstract
Using activity against Candida albicans as a lead, the bioactivity-guided fractionation of the CH2Cl2 ext. of P. piscatorum led to the isolation of the arylnaphthalide lignan justicidin B (I), which was found to be present in high amts., and a new C-11 hydroxylated deriv. that we named piscatorin (II). We provide evidence that I is the main active principle of P. piscatorum, showing the same ...
Abstract
Using activity against Candida albicans as a lead, the bioactivity-guided fractionation of the CH2Cl2 ext. of P. piscatorum led to the isolation of the arylnaphthalide lignan justicidin B (I), which was found to be present in high amts., and a new C-11 hydroxylated deriv. that we named piscatorin (II). We provide evidence that I is the main active principle of P. piscatorum, showing the same biol. effects that were found for the raw exts. I inhibited the growth of the pathogenic fungi Aspergillus fumigatus, Aspergillus flavus, and Candida albicans, but was not effective against Cryptococcus neoformans and Blastoschizomyces capitatus. I also exhibited strong activity against the trypomastigote form of Trypanosoma brucei rhodesiense and moderate activity against Trypanosoma cruzi. Testing against Plasmodium falciparum showed only weak activity. This is the 1st report on the in vitro fungicidal and antiprotozoal effects of justicidin B. In addn., both compds. exhibited a non-specific cytotoxicity in neoplastic and primary cell cultures. No antibacterial effects were detected. Both compds. were piscicidal against zebra fish and it is shown for the 1st time that I and II are the piscicidal principles of P. piscatorum, exhibiting a potency that is comparable to rotenone.
Metadata last modified: 24 May 2018 12:16
Owner only: item control page
Altmetric