Alternative links to fulltext:
| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Planta medica | ||||
| Publisher: | Thieme | ||||
| Volume: | 71 | ||||
| Number of Issue or Book Chapter: | 3 | ||||
| Page Range: | pp. 254-260 | ||||
| Date: | 2005 | ||||
| Additional Information (public): | CAN 143:109067 1-6 Pharmacology 479-13-0P (Coumestrol); 486-66-8P (Daidzein); 5768-44-5P (Pseudoisopsoralen); 119269-74-8P (Erybraedin C); 135384-00-8P (8-Prenyldaidzein); 161099-44-1P (Bidwillon C); 622368-03-0P (Bitucarpin A); 857254-94-5P (3,9-Dihydroxy-4-(3,3-dimethylallyl) [6aR,11aR]-pterocarpan); 857254-97-8P; 857349-91-8P Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (cytotoxic prenylated isoflavonoids from Bituminaria morisiana) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) | ||||
| Identification Number: |
| ||||
| Keywords: | Antitumor agents Human Leukemia Psoralea morisiana (cytotoxic prenylated isoflavonoids from Bituminaria morisiana) Isoflavonoids Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (cytotoxic prenylated isoflavonoids Flavonoids Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (pterocarpans cytotoxic prenylated isoflavonoids from Bituminaria morisiana) antitumor prenylated isoflavonoid Bituminaria isolation leukemia | ||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | No | ||||
| Item ID: | 17223 |
Abstract
Using cytotoxicity against KB cancer cells as a lead, bioguided-fractionation of the petroleum ether and Et acetate exts. of Bituminaria morisiana leaves led to the isolation of two new pterocarpans, namely 3,9-dihydroxy-4-(3,3-dimethylallyl) [6aR,11aR]-pterocarpan, 3-hydroxy-4-(3,3-dimethylallyl)-4'',5''-dehydropyrano[8,9:2'',3''][6aR,11aR]-pterocarpan and one new isoflavone identified as ...
Abstract
Using cytotoxicity against KB cancer cells as a lead, bioguided-fractionation of the petroleum ether and Et acetate exts. of Bituminaria morisiana leaves led to the isolation of two new pterocarpans, namely 3,9-dihydroxy-4-(3,3-dimethylallyl) [6aR,11aR]-pterocarpan, 3-hydroxy-4-(3,3-dimethylallyl)-4'',5''-dehydropyrano[8,9:2'',3''][6aR,11aR]-pterocarpan and one new isoflavone identified as 4',5''-dihydroxy-6''-methoxy-4'',4''-dimethyl-4'',5''-dihydro-6''H-pyrano[2'',3'':7,8]-isoflavone. Moreover, two known pterocarpans, erybraedin C and bitucarpin A, three known isoflavones, daidzein, 8-prenyldaidzein and bidwillon C, one known furocoumarin, pseudoisopsoralen and one known coumestan, coumestrol were isolated. The structures of the isolated compds. were established by 1D and 2D NMR spectroscopy, as well as mass spectrometry. Further cytotoxicity tests against cells related to the immune system (Jurkat T, Mono-Mac-6 and polymorphonuclear cells) showed a moderate activity of the known pterocarpan erybraedin C against all cell lines used (IC50 values between 17.6-28.8 micro M). In addn., erybraedin C was found to induce necrosis in leukemia Jurkat T cells.
Metadata last modified: 24 May 2018 12:16
Owner only: item control page
Altmetric