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New cytotoxic prenylated isoflavonoids from Bituminaria morisiana

Cottiglia, Filippo ; Casu, Laura ; Bonsignore, Leonardo ; Casu, Mariano ; Floris, Costantino ; Leonti, Marco ; Gertsch, Juerg ; Heilmann, Jörg


Using cytotoxicity against KB cancer cells as a lead, bioguided-fractionation of the petroleum ether and Et acetate exts. of Bituminaria morisiana leaves led to the isolation of two new pterocarpans, namely 3,9-dihydroxy-4-(3,3-dimethylallyl) [6aR,11aR]-pterocarpan, 3-hydroxy-4-(3,3-dimethylallyl)-4'',5''-dehydropyrano[8,9:2'',3''][6aR,11aR]-pterocarpan and one new isoflavone identified as ...


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