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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Journal of natural products | ||||
| Verlag: | American Chemical Society | ||||
| Band: | 71 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 7 | ||||
| Seitenbereich: | S. 1237-1241 | ||||
| Datum: | 2008 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 149:246662 30-10 Terpenes and Terpenoids 6754-58-1 Role: PAC (Pharmacological activity), BIOL (Biological study) (prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells); 37308-75-1P; 189299-03-4P; 189299-04-5P; 189299-05-6P (Xanthohumol C); 250603-94-2P; 688359-98-0P (Xanthohumol H); 1044743-34-1P; 1044743-35-2P; 1044743-36-3P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells); 123-08-0 (4-Hydroxybenzaldehyde); 480-66-0; 870-63-3 (Prenyl bromide); 6138-90-5 (Geranyl bromide) Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells); 90-24-4P; 6515-21-5P; 23121-32-6P (2-Hydroxy-4,6-dimethoxy-3-methylacetophenone); 25983-76-0P; 27364-71-2P; 30403-01-1P; 32550-59-7P; 65490-09-7P; 84092-45-5P; 90632-20-5P; 160624-22-6P; 450336-12-6P; 955950-40-0P; 1044743-37-4P; 1044743-38-5P; 1044743-39-6P; 1044743-40-9P; 1044743-41-0P; 1044743-42-1P; 1044743-43-2P; 1044743-44-3P; 1075728-02-7P; 1173195-54-4P; 1173196-14-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Antioxidants (phenolic prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells) Terpenes Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (phenolic prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells) Antitumor agents Neoplasm (prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells) Chalcones Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa Phenols Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (terpenoid prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells) prenylated geranylated Humulus lupulus chalcone prepn antitumor antioxidative activity | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 17242 |
Zusammenfassung
The minor hop (Humulus lupulus) chalcones 3'-geranylchalconaringenin (3), 5'-prenylxanthohumol (4), flavokawin (5), xanthohumol H (8), xanthohumol C (9), and 1'',2''-dihydroxanthohumol C (10) were synthesized. The non-natural chalcones 3'-geranyl-6'-O-methylchalconaringenin (2), 3'-methylflavokawin (6), and 2'-O-methyl-3'-prenylchalconaringenin (7) were also synthesized. Cytotoxicity was ...
Zusammenfassung
The minor hop (Humulus lupulus) chalcones 3'-geranylchalconaringenin (3), 5'-prenylxanthohumol (4), flavokawin (5), xanthohumol H (8), xanthohumol C (9), and 1'',2''-dihydroxanthohumol C (10) were synthesized. The non-natural chalcones 3'-geranyl-6'-O-methylchalconaringenin (2), 3'-methylflavokawin (6), and 2'-O-methyl-3'-prenylchalconaringenin (7) were also synthesized. Cytotoxicity was investigated in HeLa cells, and these compds. all had IC50 values comparable to xanthohumol (8.2-19.2 micro M). The ORAC-fluorescein assay revealed potent antioxidative activity for 7 and 8 with 5.2 and 4.8 Trolox equiv., resp.
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