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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Journal of natural products | ||||
| Verlag: | American Chemical Society | ||||
| Band: | 72 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 10 | ||||
| Seitenbereich: | S. 1741-1747 | ||||
| Datum: | 2009 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 151:396041 1-12 Pharmacology 70-18-8 (Glutathione); 7782-44-7D (Oxygen); 9000-86-6 (Alanine aminotransferase); 9000-97-9 (Aspartate aminotransferase); 148640-14-6 (Akt kinase); 169592-56-7 (Caspase-3) Role: BSU (Biological study, unclassified), BIOL (Biological study) (antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury); 6754-58-1 (Xanthohumol) Role: DMA (Drug mechanism of action), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Proteins Role: BSU (Biological study, unclassified), BIOL (Biological study) (Bcl-x antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Apoptosis Humulus lupulus Lipid peroxidation Oxidative stress Signal transduction (antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Reactive oxygen species Transcription factor NF-kB Tumor necrosis factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Flavonoids Role: DMA (Drug mechanism of action), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Injury Ischemia (hepatic antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Cytoprotective agents (hepatoprotective agents antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Liver disease (injury antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Liver disease (ischemia antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Antioxidants (natural antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Phosphorylation (protein antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) antioxidant xanthohumol hepatoprotectant liver ischemia reperfusion injury oxidative stress | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 17244 |
Zusammenfassung
Therapeutic effects of dietary flavonoids have been attributed mainly to their antioxidant capacity. Xanthohumol (1), a prominent flavonoid of the hop plant, Humulus lupulus, was investigated for its antioxidant potential and for its effect on NF-kB activation. To examine the biol. relevance of 1, a hepatic ischemia/reperfusion model was chosen as a widely accepted model of oxidative stress ...
Zusammenfassung
Therapeutic effects of dietary flavonoids have been attributed mainly to their antioxidant capacity. Xanthohumol (1), a prominent flavonoid of the hop plant, Humulus lupulus, was investigated for its antioxidant potential and for its effect on NF-kB activation. To examine the biol. relevance of 1, a hepatic ischemia/reperfusion model was chosen as a widely accepted model of oxidative stress generation. The impact of 1 on endogenous antioxidant systems, on the NF-kB signal transduction pathway as well as on apoptotic parameters, and on hepatic tissue damage was evaluated. Compd. 1 markedly decreased the level of reactive oxygen species in vitro. Furthermore, levels of enzymic and nonenzymic antioxidants were restored after pretreatment in postischemic hepatic tissue, and lipid peroxidn. was attenuated. NF-kB activity was reduced in vitro as well as in hepatic tissue after ischemia/reperfusion upon pretreatment with 1. In addn., the phosphorylation of Akt was markedly inhibited. Surprisingly, 1 decreased the expression of the antiapoptotic protein Bcl-X and increased caspase-3 like-activity, a proapoptotic parameter. Moreover, hepatic tissue damage as well as TNF-alpha levels increased in xanthohumol-pretreated liver tissue after ischemia/reperfusion. In summary, xanthohumol did not protect against ischemia/reperfusion injury in rat liver, despite its antioxidant and NF-kB inhibitory properties.
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