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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Food and chemical toxicology | ||||
| Verlag: | Elsevier | ||||
| Band: | 48 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 7 | ||||
| Seitenbereich: | S. 1890-1897 | ||||
| Datum: | 2010 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 153:165382 4-3 Toxicology 6754-58-1 (Xanthohumol) Role: ADV (Adverse effect, including toxicity), BIOL (Biological study) (xanthohumol feeding does not impair organ function and homeostasis in mice); 50-99-7 (D-Glucose); 57-13-6 (Urea); 60-27-5 (Creatinine); 7440-09-7 (Potassium); 7440-23-5 (Sodium); 9000-86-6 (ALT); 9000-97-9 (AST); 9001-62-1 (Lipase); 9005-79-2 (Glycogen); 330196-64-0 (Cytochrome P 450 1A2); 330196-93-5 (Cytochrome P 450 2E1); 343627-37-2 (Cytochrome P 450 3A11) Role: BSU (Biological study, unclassified), BIOL (Biological study) (xanthohumol feeding does not impair organ function and homeostasis in mice) | ||||
| Institutionen: | Medizin > Lehrstuhl für Innere Medizin I Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | CD antigens Role: BSU (Biological study, unclassified), BIOL (Biological study) (CD54 xanthohumol feeding does not impair organ function and homeostasis in mice) Cell adhesion molecules Role: BSU (Biological study, unclassified), BIOL (Biological study) (ICAM-1 (intercellular adhesion mol. 1) xanthohumol feeding does not impair organ function and homeostasis in mice) Proteins Role: BSU (Biological study, unclassified), BIOL (Biological study) (blood xanthohumol feeding does not impair organ function and homeostasis in mice) Toxins Role: BSU (Biological study, unclassified), BIOL (Biological study) (endotoxins xanthohumol feeding does not impair organ function and homeostasis in mice) Liver disease (fibrosis xanthohumol feeding does not impair organ function and homeostasis in mice) Fibrosis Injury (hepatic xanthohumol feeding does not impair organ function and homeostasis in mice) Liver disease (injury xanthohumol feeding does not impair organ function and homeostasis in mice) Collagens Role: BSU (Biological study, unclassified), BIOL (Biological study) (type I xanthohumol feeding does not impair organ function and homeostasis in mice) Animal organ Biomarkers Blood serum Colon Growth Heart Hepatitis Hepatotoxicity Homeostasis Human Humulus lupulus Kidney Liver Lung Pancreas Spleen Thymus gland (xanthohumol feeding does not impair organ function and homeostasis in mice) Albumins Cytokines Enzymes Gene Interleukin 1alpha Monocyte chemoattractant protein-1 Transforming growth factor beta Tumor necrosis factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (xanthohumol feeding does not impair organ function and homeostasis in mice) xanthohumol feeding organ function homeostasis toxicity xanthohumol feeding | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 17249 |
Zusammenfassung
Xanthohumol, the major prenylated chalcone found in hops, is known to exert several beneficial effects but only few studies evaluated the safety profile of this natural compd. with in part discrepant results. Here, the authors fed female BALB/c mice with a std. diet supplemented with xanthohumol for 3 wk, and thus, achieved a daily dose of .apprx.1000 mg xanthohumol/kg body wt. There were no ...
Zusammenfassung
Xanthohumol, the major prenylated chalcone found in hops, is known to exert several beneficial effects but only few studies evaluated the safety profile of this natural compd. with in part discrepant results. Here, the authors fed female BALB/c mice with a std. diet supplemented with xanthohumol for 3 wk, and thus, achieved a daily dose of .apprx.1000 mg xanthohumol/kg body wt. There were no significant differences in body wt. or food intake between mice on std. diet and animals receiving the same diet supplemented with xanthohumol. Histopathol. examn. of the liver, kidney, colon, lung, heart, spleen, and thymus revealed no signs of xanthohumol toxicity, and biochem. serum anal. confirmed normal organ function. Further, xanthohumol treatment did not affect hepatic glycogen content, CYP2E1 and CYP1A2 expression levels, but CYP3A11 mRNA was .apprx.30% reduced. Expression of several genes indicative of early hepatic inflammation and fibrosis, a hallmark of chronic liver injury, did not differ between xanthohumol treated and control mice. Thus, oral administration of xanthohumol exhibited no adverse effects on major organ function and homeostasis in mice. Particularly, hepatotoxic effects could be ruled out confirming a good safety profile of xanthohumol as a prerequisite for further studies in humans.
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