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Establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands

Geiger, Sarah ; Nickl, Kathrin ; Schneider, Erich H. ; Seifert, Roland ; Heilmann, Jörg


Cannabinoid receptors (CBR) are important drug targets for the treatment of various inflammatory, metabolic and neurol. diseases. Therefore, sensitive test systems for the assessment of ligands are needed. In this study, a steady-state GTPase assay for human CBR subtypes 1 and 2 was developed to characterize the pharmacol. property of ligands at a very proximal point of the signal transduction ...


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