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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Phytomedicine | ||||
| Verlag: | Elsevier | ||||
| Band: | 17 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 1 | ||||
| Seitenbereich: | S. 19-22 | ||||
| Datum: | 2010 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 153:222178 1-11 Pharmacology 154-23-4 ((+)-Catechin) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) ((+)-catechin did not show affinity for recombinant human cannabinoid receptor 1 and 2 in Chem-1 and Chinese hamster ovary cell); 490-46-0 ((-)-Epicatechin) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) ((-)-epicatechin did not show affinity for recombinant human cannabinoid receptor 1 and 2 in Chem-1 and Chinese hamster ovary cell); 1257-08-5 ((-)-Epicatechin-3-O-gallate) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) ((-)-epicatechin-3-O-gallate from Camellia sinensis leaf showed affinity for recombinant human cannabinoid receptor 1 and 2 in Chem-1 and Chinese hamster ovary cell); 970-74-1 ((-)-Epigallocatechin) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) ((-)-epigallocatechin from Camellia sinensis leaf showed affinity for recombinant human cannabinoid receptor 1 and 2 in Chem-1 and Chinese hamster ovary cell); 989-51-5 ((-)-Epigallocatechin-3-O-gallate) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) ((-)-epigallocatechin-3-O-gallate from Camellia sinensis leaf showed affinity for recombinant human cannabinoid receptor 1 and 2 in Chem-1 and Chinese hamster ovary cell) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Cannabinoid receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) ((-)-epigallocatechin-3-O-gallate, (-)-epigallocatechin, (-)-epicatechin-3-O-gallate from Camellia sinensis leaf showed moderate affinity for human cannabinoid rec Ovary ((-)-epigallocatechin-3-O-gallate, (-)-epigallocatechin, (-)-epicatechin-3-O-gallate from Camellia sinensis leaf showed weaker affinity for recombinant human cannabinoid receptor 2 in Chem-1 and Chinese hamster ovary cell) Camellia sinensis Human Leaf ((-)-epigallocatechin-3-O-gallate, (-)-epigallocatechin, (-)-epicatechin-3-O-gallate from Camellia sinensis leaf showed while (+)-catechin, (-)-epicatechin did not show affinity for recombinant human CB1 and CB2 in Chem-1 and CHO cell) Central nervous system (central nervous cannabinoid receptor was targeted by Camellia sinensis catechin in Chem-1 and Chinese hamster ovary cell) Camellia leaf recombinant human cannabinoid receptor ovary catechin epigallocatechin | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 17253 |
Zusammenfassung
Among the many known health benefits of tea catechins count anti-inflammatory and neuroprotective activities, as well as effects on the regulation of food intake. Here we address cannabimimetic bioactivity of catechin derivs. occurring in tea leaves as a possible cellular effector of these functionalities. Competitive radioligand binding assays using recombinant human cannabinoid receptors ...
Zusammenfassung
Among the many known health benefits of tea catechins count anti-inflammatory and neuroprotective activities, as well as effects on the regulation of food intake. Here we address cannabimimetic bioactivity of catechin derivs. occurring in tea leaves as a possible cellular effector of these functionalities. Competitive radioligand binding assays using recombinant human cannabinoid receptors expressed in Chem-1 and CHO cells identified (-)-epigallocatechin-3-O-gallate, EGCC (Ki = 33.6 micro M), (-)-epigallocatechin, EGC (Ki=35.7 micro M), and (-)-epicatechin-3-O-gallate, ECG (Ki=47.3 micro M) as ligands with moderate affinity for type 1 cannabinoid receptors, CB1. Binding to CB2 was weaker with inhibition consts. exceeding 50 micro M for EGC and ECG. The epimers (+)-catechin and (-)-epicatechin exhibited negligible affinities for both CB1 and CB2. It can be concluded that central nervous cannabinoid receptors may be targeted by selected tea catechins but signaling via peripheral type receptors is less likely to play a major role in vivo.
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