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The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat

Monti, J. M. ; Jantos, H. ; Leschke, C. ; Elz, Sigurd ; Schunack, W.



Abstract

The effects of the selective histamine H1-receptor agonist, 2-(3-trifluoromethylphenyl)histamine, were studied in rats implanted with electrodes for chronic sleep recordings. 2-(3-Trifluoromethylphenyl)histamine (80-120 micrograms) injected into the left lateral ventricle increased wakefulness, whereas slow wave sleep was reduced. Pretreatment with pyrilamine (2.0 mg/kg) prevented the effects of ...

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