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[7-fluoro-4-chromone-3-sulfur compounds]

Lowe, W., Elz, Sigurd, Reiser, H. and Schott, S. (1994) [7-fluoro-4-chromone-3-sulfur compounds]. Archiv der Pharmazie 327 (4), pp. 267-269.

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The novel 7-fluoro-4-chromone-3-sulfur compounds 5-12 were synthesized from the sulfinic acid 4, which can be obtained from the enaminone 3 and thionyl chloride. Especially the Flosequinane-like sulfoxide 12 was prepared and the vasodilating activity was evaluated in isolated ring segments of rat aorta.

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Item type:Article
Additional Information (public):Lowe, W Elz, S Reiser, H Schott, S English Abstract In Vitro Germany Archiv der Pharmazie Arch Pharm (Weinheim). 1994 Apr;327(4):267-9.
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
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Keywords:Animals Aorta, Thoracic/drug effects Chromones/*chemical synthesis/pharmacology Male Muscle, Smooth, Vascular/drug effects Rats Rats, Wistar Vasodilator Agents/*chemical synthesis/pharmacology
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:17291
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