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Histamine analogues. 36th communication. Basically substituted histamine derivatives with H1-agonistic activity

Zingel, V. ; Elz, Sigurd ; Schunack, W.



Abstract

Piperidinoalkyl-, morpholinoalkyl- or [(pyrid-2-yl)methylthio]alkyl-substituents were introduced into position 2 of the essential histamine structure. These 2-substituted histamine derivatives were prepared via reaction of imidate hydrochlorides in liquid ammonia under pressure with 1,3-dihydroxypropanone followed by a stepwise build-up of the side chain in position 4 of the imidazole nucleus ...

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