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Model evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics
Brusch, Lutz, Cuniberti, Gianaurelio
and Bertau, Martin
(2004)
Model evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics.
Biophysical Chemistry 109 (3), pp. 413-426.
Date of publication of this fulltext: 05 Aug 2009 13:31
Article
DOI to cite this document: 10.5283/epub.1734
Abstract
Anaerobic glycolysis in yeast perturbed by the reduction of xenobiotic ketones is studied numerically in two models which possess the same topology but different levels of complexity. By comparing both models' predictions for concentrations and fluxes as well as steady or oscillatory temporal behavior we answer the question what phenomena require what kind of minimum model abstraction. While mean ...
Anaerobic glycolysis in yeast perturbed by the reduction of xenobiotic ketones is studied numerically in two models which possess the same topology but different levels of complexity. By comparing both models' predictions for concentrations and fluxes as well as steady or oscillatory temporal behavior we answer the question what phenomena require what kind of minimum model abstraction. While mean concentrations and fluxes are predicted in agreement by both models we observe different domains of oscillatory behavior in parameter space. Generic properties of the glycolytic response to ketones are discussed. (C) 2003 Elsevier B.V. All rights reserved.
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Details
| Item type | Article | ||||||
| Journal or Publication Title | Biophysical Chemistry | ||||||
| Publisher: | ELSEVIER SCIENCE BV | ||||||
|---|---|---|---|---|---|---|---|
| Place of Publication: | AMSTERDAM | ||||||
| Volume: | 109 | ||||||
| Number of Issue or Book Chapter: | 3 | ||||||
| Page Range: | pp. 413-426 | ||||||
| Date | June 2004 | ||||||
| Institutions | Physics > Institute of Theroretical Physics > Alumni or Retired Professors > Group Gianaurelio Cuniberti | ||||||
| Identification Number |
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| Keywords | SACCHAROMYCES-CEREVISIAE; BAKERS-YEAST; BIOCHEMICAL NETWORKS; REDUCTION; DYNAMICS; CALCIUM; ESTERS; GENE; TRANSDUCTION; ENZYMES; glycolysis; metabolic oscillations; model; biotransformation | ||||||
| Dewey Decimal Classification | 500 Science > 530 Physics | ||||||
| Status | Published | ||||||
| Refereed | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg | Yes | ||||||
| URN of the UB Regensburg | urn:nbn:de:bvb:355-epub-17346 | ||||||
| Item ID | 1734 |
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