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G protein-coupled receptors function as logic gates for nanoparticle binding and cell uptake

Hild, Wolfgang ; Pollinger, Klaus ; Caporale, Andrea ; Cabrele, Chiara ; Keller, Max ; Pluym, Nicola ; Buschauer, Armin ; Rachel, Reinhard ; Tessmar, Joerg ; Breunig, Miriam ; Goepferich, Achim



Abstract

More selective interactions of nanoparticles with cells would substantially increase their potential for diagnostic and therapeutic applications. Thus, it would not only be highly desirable that nanoparticles can be addressed to any cell with high target specificity and affinity, but that we could unequivocally define whether they rest immobilized on the cell surface as a diagnostic tag, or if ...

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