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Zusammenfassung
The effects of the estrogen 4,4'-DES-epoxide and the antistrogens, 3,3'-DES-epoxide, 3,3'-dihydroxy-alpha ,beta -diethylstilbene, and 3,4-di(hydroxyphenyl)hexane, were studied on estrogen and progesterone-contg. pre- and postmenopausal serially transplanted human breast tumors in nude mice. Treatment of premenopausal tumors with the 4 steroids or ovariectomy plus aminoglutethimide plus tamoxifen ...
Zusammenfassung
The effects of the estrogen 4,4'-DES-epoxide and the antistrogens, 3,3'-DES-epoxide, 3,3'-dihydroxy-alpha ,beta -diethylstilbene, and 3,4-di(hydroxyphenyl)hexane, were studied on estrogen and progesterone-contg. pre- and postmenopausal serially transplanted human breast tumors in nude mice. Treatment of premenopausal tumors with the 4 steroids or ovariectomy plus aminoglutethimide plus tamoxifen [10540-29-1] or aminoglutethimide plus tamoxifen was without effect on tumor growth. However, in postmenopausal tumor the 4 steroids markedly decreased tumor growth. Evidently, these antiestrogens were effective against postmenopausal but not premenopausal breast tumor growth.