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Studies on the mammary tumor inhibiting effect of cis-bis(glycylglycin ethyl ester)platinum(II) chloride

Seidenberger, Horst, Kranzfelder, Gerhard, Wappes, Beate, Schönenberger, Helmut, Beck, Wolfgang and Girnth, Michael (1981) Studies on the mammary tumor inhibiting effect of cis-bis(glycylglycin ethyl ester)platinum(II) chloride. Archiv der Pharmazie 314 (11), pp. 955-967.

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Abstract

In vivo, cis-dichlorodiammineplatinum(II) (I) [15663-27-1] and cis-dichlorobis(glycylglycine Et ester)platinum(II) (II) [60426-60-0] inhibited the DMBA-induced hormone-dependent mammary carcinoma of the SD rat. In vitro, a marked effect on DNA synthesis by mammary tumor cells and an inhibition of estradiol-receptor interaction by I and II were demonstrated. Binding to DNA and inhibition of the ...

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Item type:Article
Date:1981
Additional Information (public):CAN 96:28366 1-6 Pharmacology 15663-27-1; 60426-60-0 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by, mechanism of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1982:28366Other
Keywords:Receptors Role: BIOL (Biological study) (for estrogens, cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum inhibition of estrogens interaction with, neoplasm inhibition mechanism in relation to) Estrogens Role: BIOL (Biological study) (receptors for, cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum interaction with, neoplasm inhibition mechanism in relation to) Neoplasm inhibitors (cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum as) Deoxyribonucleic acid formation (cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum inhibition of, neoplasm inhibition mechanism in relation to) cis platinum antitumor mechanism
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17631
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