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Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha ,beta -dialkylstilbenes and of related stilbene oxides

Schneider, Martin R., Schönenberger, Helmut, Michel, Ralf T. and Fortmeyer, H. P. (1982) Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha ,beta -dialkylstilbenes and of related stilbene oxides. Journal of medicinal chemistry 25 (2), pp. 141-145.

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3,3'-Diacetoxy-alpha ,beta -dialkylstilbenes (C1-4 alkyl), 3,3'-dihydroxy-alpha ,beta -diethylstilbene (I) [80149-87-7], and their corresponding stilbene oxides were synthesized. These compds. competitively antagonized in vitro the interaction of 3H-labeled estradiol [50-28-2] with its receptor. 3,3'-diacetoxy-alpha ,beta -diethylstilbene [80149-84-4], 3,3'-diacetoxy-alpha ,beta -diethylstilbene ...


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Item type:Article
Additional Information (public):CAN 96:46387 2-2 Mammalian Hormones 80149-92-4; 80149-93-5; 80149-94-6 Role: RCT (Reactant), RACT (Reactant or reagent) (acetylation of); 78515-20-5P; 80149-84-4P; 80149-85-5P; 80149-86-6P; 80149-87-7P; 80149-88-8P; 80149-89-9P; 80149-90-2P; 80149-91-3P; 80149-95-7P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and neoplasm-inhibiting activity of); 50-28-2 Role: BIOL (Biological study) (receptor binding of, stilbene derivs. inhibition of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
Keywords:Receptors Role: PROC (Process) (for estrogen, stilbene derivs. antagonism of) Estrogens Role: BIOL (Biological study) (receptor for, stilbene derivs. antagonism of) Neoplasm inhibitors (stilbene derivs. as) Mammary gland (neoplasm, stilbene derivs. inhibition of) Molecular structure-biological activity relationship (neoplasm-inhibiting, of stilbene derivs.) mammary neoplasm inhibitor stilbene structure activity stilbene
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17637
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