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Mechanism of action of cis-bis(glycylglycineethyl ester)platinum(II) chloride - effect on protein biosynthesis

Seidenberger, Horst ; Schönenberger, Helmut ; Beck, Wolfgang ; Girnth-Weller, Michael



Abstract

The effect of cis-bis(glycylglycine Et ester)platinum(II) chloride [60426-60-0] and cisplatinum [15663-27-1] on the protein biosynthesis of Walker-25 carcinosarcoma was confirmed to arise from an inhibition of the aminoacylation of tRNA and the biosynthesis of polyphenylalanine. Expts. were conducted in a cell-free system using poly-U as exogenous messenger.


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