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Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism

Seidenberger, Horst ; Schönenberger, Helmut ; Beck, Wolfgang ; Girnth-Weller, Michael ; Lux, Franz ; Zeisler, Rolf


cis-bis(glycylglycinethylester)platinum II chloride (I) [60426-60-0] interfered with the nucleic acid metab. in tumor cells by inhibiting the DNA template activity as well as the DNA- [9012-90-2] and RNA polymerase [9014-24-8] and the ribonucleotide reductase [9040-57-7] system. The activity of I was similar to the therapeutically used Pt coordination complex cis-Pt(NH3)2Cl2.

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