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Relations between structure and antitumor activity of cis-dichloro[bis(oligopeptide ester)platinum(II)] complexes

Seidenberger, Horst ; Wappes, Beate ; Schönenberger, Helmut ; Beck, Wolfgang ; Girnth-Weller, Michael ; Ruckdeschel, Gotthart



Abstract

Several title compds., cis- and trans-[PtA2X2] complexes (A = esters of oligopeptides; X = Cl, oxalate, or malonate), were tested for their ability to inhibit thymidine 3H incorporation by suspensions by ADJ/PC6 plasmacytoma cells, as an index of antitumor action. The effect was markedly dependent on the type, no., and sequence of the amino acids in the peptide component. The most active compd. ...

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