Go to content
UR Home

Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols

Hartmann, Rolf W. ; Heindl, Alexander ; Schönenberger, Helmut


Sym. 4,4'-, 5,5'-, and 6,6'-disubstituted derivs. of the mammary tumor-inhibiting antiestrogen metahexestrol (meso-I, R = H) (II) were prepd. Reductive coupling of EtCOC6H4R with TiCl4/Zn followed by hydrogenation, or reductive coupling of EtCH(OH)C6H4R with TiCl3/LiAlH4, and sepn. of the diastereomers, or substitution reaction of II gave meso-I (R = Me, MeOCH2, EtOCH2, HOCH2, halo, NO2, OH, ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons