Go to content
UR Home

Ring-substituted 1,1,2,2-tetraalkylated 1,2-bis(hydroxyphenyl)ethanes. 4. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted 1,1,2,2-tetramethyl-1,2-bis(hydroxyphenyl)ethanes

Hartmann, Rolf W. ; Schwarz, Walter ; Heindl, Alexander ; Schönenberger, Helmut



Abstract

The title compds. I (R = R1 = H, Cl, F, Me, MeO, OH) prepd. by coupling the corresponding substituted 2-(methoxyphenyl)-2-propanol using TiCl3/LiAlH4 and subsequent ether cleavage of the products, were evaluated for estrogenic, antiestrogenic, and mammary tumor-inhibiting activities. The relative binding affinity was detd. by displacement of [3H]estradiol after incubation with calf uterine ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons