Go to content
UR Home

Ring-substituted 1,1,2,2-tetraalkylated 1,2-bis(hydroxyphenyl)ethanes. 4. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted 1,1,2,2-tetramethyl-1,2-bis(hydroxyphenyl)ethanes

Hartmann, Rolf W. ; Schwarz, Walter ; Heindl, Alexander ; Schönenberger, Helmut


The title compds. I (R = R1 = H, Cl, F, Me, MeO, OH) prepd. by coupling the corresponding substituted 2-(methoxyphenyl)-2-propanol using TiCl3/LiAlH4 and subsequent ether cleavage of the products, were evaluated for estrogenic, antiestrogenic, and mammary tumor-inhibiting activities. The relative binding affinity was detd. by displacement of [3H]estradiol after incubation with calf uterine ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons